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Image Search Results
Journal: Disease Models & Mechanisms
Article Title: Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels
doi: 10.1242/dmm.027300
Figure Lengend Snippet: Loss of CAV1 in the intestinal epithelia alters plasma cholesterol levels. (A) In male mice, total and esterified plasma cholesterol are elevated by HFD compared with LFD in WT, but not CAV1 IEC-KO (IKO), mice following a 4 h fast ( n =5-8). (B) Conversely, for female mice, total, free, and esterified plasma cholesterol are elevated by HFD compared with LFD in 4 h fasted CAV1 IEC-KO , but not WT, mice ( n =8-9). (C) Postprandial male CAV1 IEC-KO mice fed CD have greater plasma-free cholesterol mice than WT ( n =6-8). Data are mean±s.e.m, two-way ANOVA, * P <0.05; groups with different brackets show an effect of diet, groups with different letters are significantly different by post hoc testing.
Article Snippet: Kits were used to measure total
Techniques: Clinical Proteomics
Journal: Disease Models & Mechanisms
Article Title: Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels
doi: 10.1242/dmm.027300
Figure Lengend Snippet: Lipoprotein cholesterol levels are affected by loss of CAV1 in the intestinal epithelia. (A,B) Male CAV1 IEC-KO (IKO) mice are protected from HFD-induced increase in fasted plasma LDL cholesterol ( n =6-10, mean±s.e.m, two-way ANOVA, significant interaction between diet and genotype) (A), but female mice are not ( n =8-9) (B). Female CAV1 IEC-KO , but not WT, mice have higher fasted plasma HDL cholesterol on HFD than LFD. Mean±s.e.m, two-way ANOVA, groups with different letters are significantly different by post hoc testing. (C) CAV1 IEC-KO mice on CD have higher postprandial plasma LDL cholesterol than WT mice. Mean±s.e.m, Student's t -test, * P <0.05, n =6-9.
Article Snippet: Kits were used to measure total
Techniques: Clinical Proteomics